Fiprotec Combo

Fiprotec Combo Spot-On


Liquid Spot-on

Active ingredient

Fipronil, (S)-methoprene

Frequency of use

Every 4 weeks

Minimum age/weight

8 weeks (2kg)


Fleas (adults), Fleas (immature), Biting lice and Ticks

What is Fiprotec Combo?

Fiprotec combo is a dual-action, non-prescription spot-on flea and tick treatment. It works by combining two ingredients – Fipronil, an adulticide, and (S)-methoprene, an insect growth regulator. It kills fleas and ticks for 4 weeks after topical application.

What does Fiprotec Combo do?

Fiprotec Combo contains two active ingredients, fipronil, and (S)-methoprene. This is how they both work:

  • Fipronil: This active ingredient acts as a neurotoxin. When ticks or fleas come into contact with fipronil, it disrupts their nervous system causing paralysis and death. It is a broad-spectrum insecticide and acaricide. When applied, it spreads across your pet’s skin and hair follicles through the sebum (skin oils).
  • (S)-Methoprene: This ingredient interrupts the flea life cycle by acting as an insect growth regulator. It mimics a natural insect hormone, causing flea eggs to be infertile and preventing larvae from developing into adults. By interrupting the flea life cycle, (S)-methoprene helps control and prevent infestations.

Once applied, Fiprotec Combo is stored in the oil glands of your pet’s skin, providing a sustained release over time. This ensures continuous protection against fleas and ticks, maintaining a flea-free and comfortable environment for your furry companion.

What is Fiprotec Combo for?

Fiprotec Combo helps control ectoparasites (parasites that live on your pet’s skin) in the following situations:

  • Flea Infestations: If your pet is dealing with a current flea problem, Fiprotec Combo kills adult fleas, putting an end to the itching and discomfort. It also interrupts the growth cycle of the fleas, getting an infestation under control more quickly than an adulticide-only medication.
  • Tick Control: Fiprotec Combo kills ticks, preventing potential diseases transmitted by these parasites.

What are the possible side effects with Fiprotec Combo?

Fiprotec Combo is generally well-tolerated, but it’s essential to be aware of potential side effects. These can include:

  • Redness and skin irritation: Very rarely, pets may experience temporary skin irritation at the application site. This typically is very mild and usually resolves on its own.
  • Hair loss at the site of application: Some pets might experience hair loss at the application site. This is rare and usually cosmetic. Hair usually regrows after the treatment period.
  • Excessive itching: Occasionally, pets may exhibit increased itching. This is typically a temporary reaction to the application and tends to resolve on its own.
  • Excessive Salivation: Some cats may start hypersalivating (drooling) after application. This can be due to licking, so may be prevented by applying the liquid high enough on the back of the neck so the pet cannot lick this area.
  • Nausea and Vomiting: Very rarely, vomiting is reported as a side effect.
  • Respiratory signs (unusual breathing): In rare cases, breathing problems have been reported after use.

Remember, these side effects are not frequently seen, and the benefits of Fiprotec Combo in preventing flea and tick infestations far outweigh the risks. If you have any concerns or notice persistent changes in your pet, consulting your vet will provide reassurance and guidance.

How to give Fiprotec Combo safely

Using Fiprotec Combo safely on your pet requires following proper application techniques and precautions. Here’s a step-by-step guide to ensure safe and effective use:
Before application

  • Consult your veterinarian: Discuss your pet’s health, any existing conditions, and whether Fiprotec Combo is the right choice. They can determine the appropriate dosage based on your pet’s weight and species.
  • Read the product instructions carefully: Each version of Fiprotec Combo might have specific instructions. Familiarize yourself with the contents, dosage guidance, and application method to avoid errors.
  • Gather supplies: You’ll need the Fiprotec Combo tube, gloves (optional), and a towel (optional).

Application process

  • Choose the application site: Apply the solution directly to the back of your pet’s neck between the shoulder blades. This area is less accessible for licking and ensures optimal absorption.
  • Part the fur: Gently part the fur to reveal the skin at the application site.
  • Hold the tube upright: Point the nozzle away from your pet and yourself.
  • Apply the solution: Squeeze the tube gently, depositing the required amount of solution directly onto the exposed skin. Avoid applying to broken skin or wounds.
  • Do not massage: Allow the solution to spread naturally on your pet’s skin.
  • Discard the used tube safely.

After application

  • Wash your hands thoroughly.
  • Monitor your pet: Observe your pet for any immediate reactions like excessive scratching or discomfort. Contact your vet if you notice any concerning signs.
  • Keep your pet away from water for 24 hours: This allows the solution to dry and become effective.
  • Do not bathe your pet for 2 days:
  • Prevent licking: Use an Elizabethan collar (cone) if your pet tends to lick or chew at the application site.

Additional safety tips

  • Do not use the product on pets less than 8 weeks old and/or weighing less than 2kg.
  • Do not use on sick pets.
  • Do not use if your pet has a hypersensitivity to fipronil or S-methoprene
  • Do not apply on wounds or damaged skin.
  • Store Fiprotec Combo in a cool, dry place, out of reach of children and pets.
  • Never use Fiprotec Combo on rabbits or horses, as it can be fatal to them.
  • Do not overdose. Stick to the recommended dosage prescribed by your veterinarian.
  • Do not apply Fiprotec Combo more frequently than recommended. Overuse can be harmful to your pet.

Fiprotec Combo FAQs

Is FIPROtec the same as Frontline?

Fiprotec and Frontline are not the same, but they do share some similarities. Here’s a breakdown to help you understand the differences:

Active ingredient: Both Fiprotec and Frontline primarily contain fipronil, a broad-spectrum insecticide effective against fleas and ticks. This means they offer similar protection against these parasites.
Application method: Both are applied as spot-on solutions directly to the pet’s skin, typically between the shoulder blades.
Duration of action: Both offer protection for several weeks, typically 4 weeks for dogs and cats.
Additional ingredients: Fiprotec contains s-methoprene, an insect growth regulator that prevents flea eggs from hatching and larvae from maturing. Frontline typically does not have this ingredient.
Target animals: Fiprotec is available for both dogs and cats, while some versions of Frontline are only approved for dogs or cats.
Brand and manufacturer: Fiprotec is produced by Beaphar, while Frontline is produced by Boehringer Ingelheim.

How long does FIPROtec COMBO take to work?

The timeframe for Fiprotec Combo’s effectiveness depends on the specific target and outcome you’re looking for:

Killing Adult Fleas and Ticks:

Fipronil, the primary insecticide in Fiprotec Combo, starts working rapidly. It begins affecting these parasites within 24 hours after application, and most adult fleas and ticks will be dead within 24-48 hours. So, you can expect relief from itching and scratching relatively quickly.

Preventing Future Flea Infestations:

S-methoprene, the insect growth regulator, takes a bit longer to show its effect. It acts primarily on flea eggs and larvae, preventing them from developing into biting adults. This starts within 24-48 hours, but the full impact takes around 6-8 weeks as existing eggs and larvae complete their life cycle and cannot reproduce.


You can expect immediate relief from existing flea and tick problems within a day or two.

Complete protection against future flea infestations takes around 6-8 weeks with consistent use every 4 weeks.

How often can you use FIPROtec COMBO?

The frequency of Fiprotec Combo application depends on your specific goals and the circumstances, but generally falls within these guidelines:
For continuous flea and tick prevention:
Recommended: Apply every 4 weeks for both dogs and cats. This ensures ongoing protection against both adult parasites and prevents fleas from hatching and maturing, effectively breaking the flea breeding cycle.

Does FIPROtec kill flea eggs?

No, Fiprotec alone does not directly kill flea eggs. However, it offers valuable protection against future flea infestations in two ways:

  1. Eliminating Adult Fleas: Fiprotec’s primary active ingredient, fipronil, is a potent insecticide that quickly kills adult fleas on your pet within 24-48 hours. By breaking the breeding cycle of adult fleas, you significantly reduce the chances of new eggs being laid.
  2. Inhibiting Development: While Fiprotec itself doesn’t directly kill flea eggs, it contains another key ingredient called s-methoprene, which acts as an insect growth regulator (IGR). S-methoprene disrupts the hormonal development of flea eggs and larvae, preventing them from maturing into biting adults. This effectively halts the next generation of fleas from infesting your pet and your home.

Therefore, while Fiprotec doesn’t directly kill existing flea eggs, its potent action against adult fleas and its inclusion of an IGR provides a powerful two-pronged approach to prevent future outbreaks. Remember, consistent application every 4 weeks is crucial for optimal protection and to break the flea breeding cycle completely.

Fiprotec Combo Datasheet

All drugs have a manufacturer’s datasheet, which gives information about the drug’s use and possible side effects. There is usually one in your Fiprotec Combo box, but if you have lost it you can click on the button below to be taken on an online version.

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Please note that the information contained herein is provided for informational purposes only. Although it has been written by a vet, we cannot consider the individual nature of your pet’s problems so it does not constitute veterinary advice. If you have questions about your pet’s medication or their health you should contact a vet, who will be able to help.