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Galliprant for dogs



Active ingredient



Pain relief / anti-inflammatory

What is Galliprant?

Galliprant is a brand name for a drug with the active ingredient grapiprant. It is a Non-Steroidal Anti-Inflammatory Drug (NSAID), a type of drug that decreases the body’s production of inflammatory chemicals. In this way, Galliprant manages pain and inflammation in dogs with mild to moderate degenerative joint disease (osteoarthritis).

What does Galliprant do?

Grapiprant, the active ingredient in Galliprant, is known as a Non-Steroidal Anti-Inflammatory Drug (NSAID). Galliprant blocks the action of EP4 receptors in the body. EP4 receptors play a part in the pain and inflammation associated with osteoarthritis.

By blocking the action of EP4 receptors, Galliprant reduces pain and inflammation associated with osteoarthritis in dogs. Thus, dogs with mild to moderate osteoarthritis can enjoy an improved quality of life with Galliprant.

What is Galliprant for?

Galliprant is used to manage pain and inflammation associated with mild to moderate osteoarthritis in dogs. This improves their mobility and comfort.

What are the possible side effects with Galliprant?

Galliprant (grapiprant) is generally well-tolerated in dogs. However, like any medication, it may have potential side effects. It’s important for pet owners to be aware of these possible reactions. Speak to your vet immediately if you notice any of these signs in your dog.
Possible side effects of Galliprant include:

  • Gut Upset: Some dogs may experience gut upset. Signs of gut upset include  vomiting and/or diarrhoea. 
  • Sores on gut lining (gut ulcers): Prolonged use or higher doses of Galliprant may cause gut ulcers. Signs include tarry stools and/or fresh blood in the vomit/diarrhoea.
  • Decreased Appetite: Galliprant can cause some dogs to eat less.
  • Tiredness (Lethargy): Galliprant can cause tiredness in some dogs. 
  • Low Protein Levels: Higher doses of Galliprant can lower the body’s total protein levels, which can cause issues like weakness, decreased appetite and bloating. Low protein levels may be reversed when treatment is stopped.
  • Kidney Damage: NSAIDs, including Galliprant, can affect kidney function. It’s essential to monitor for signs of increased thirst, changes in urination, or lethargy, which may indicate kidney issues.
  • Liver Damage: While rare, liver damage may occur. Regular monitoring may be recommended.
  • Allergic Reactions: In very rare cases, dogs may experience an allergic reaction, characterised by swelling, itching, or difficulty breathing.

Remember, not all pets will experience these side effects, and the benefits of using Galliprant often outweigh the risks, especially in pets with serious health conditions. However, if you notice any concerning signs or changes in your pet’s behaviour or health while they are taking Galliprant, please contact your vet immediately. They can provide guidance and adjust the treatment plan if necessary to ensure your pet’s safety and well-being.

Which pets is Galliprant not suitable for?

Generally speaking, Galliprant is not suitable for the following pets:

  • Dogs allergic to Galliprant, its ingredients or any other NSAID (Galliprant tablets are flavoured)
  • Dogs that are already on other anti-inflammatory drugs (e.g. other NSAIDs, corticosteroids).
  • Dogs that are pregnant, lactating or intended for breeding
  • Dogs under 9 months of age
  • Dogs weighing less than 3.6kg
  • Dogs with bleeding disorders
  • Dogs with dehydration, heart problems, kidney problems and liver problems

The above pets are at a greater risk of side effects from Galliprant.

If your dog has any of the above issues and your vet prescribes Galliprant, your vet will discuss the risks involved and the importance of close monitoring.

How to give Galliprant safely

  • Follow vet instructions: Generally speaking, Galliprant can be given with or without food. Also, absorption is best when Galliprant is given on an empty stomach (although you need to tell your vet immediately if your dog experiences side effects after being fed Galliprant on an empty stomach). However, always use Galliprant exactly as your vet has prescribed. This includes the right dose and frequency. Never change the dose on your own, even if your dog seems to be feeling better or worse. If you aren’t sure of the dose prescribed, please call your vet to confirm.
  • Check with your vet if giving anything else: Your vet should know about other drugs that your pet is on. However, do double-check in case there has been a misunderstanding somewhere. If your dog is on supplements or non-prescription treatments, you should also tell your vet when they prescribe Galliprant, as they may not be suitable to be given together.

    If Galliprant has been prescribed to a dog while they are already on other anti-inflammatory medications (e.g. other NSAIDs, corticosteroids), the dog is at an increased risk of side effects. If your vet wishes to switch your dog from another anti-inflammatory drug to Galliprant or vice versa,  your dog will be taken off the previous anti-inflammatory for a certain amount of time (a “washout period”) before being started on the next anti-inflammatory.  Therefore, you should also tell your vet about your dog’s past medications.
  • Storage and Handling: Store Galliprant according to the instructions on the label, usually in a cool and dry place. Make sure it’s out of reach of children and other pets.
  • Report any accidental overdose to your vet immediately: If you have mistakenly given too much Galliprant, inform your vet as soon as you realise the error. They may recommend blood tests, intravenous fluids, and/or monitoring, depending on the severity of the overdose.

Galliprant FAQs

What is the best time of day to give Galliprant?

The best time of day to give Galliprant is the time specified by your vet. Generally speaking, Galliprant is usually given once a day (either in the morning or at night), and it is generally given at the same time each day. Speak to your vet for specific advice.

Is Galliprant a good pain reliever for dogs?

Yes, Galliprant is a good pain reliever for dogs with mild and moderate osteoarthritis. Two major studies were done on dogs with osteoarthritis. After 28 days of treatment, the dogs on Galliprant had improved compared to those on a placebo treatment.

How many hours does Galliprant last?

The effects of Galliprant usually last about 24-72 hours, with Galliprant lasting longer in dogs with liver and/or kidney issues. Galliprant is usually given once every 24 hours.

How long does it take for Galliprant to start working in dogs?

It takes about 1-2 hours for Galliprant to start working in dogs. If there is no visible improvement in dogs after 14 days, speak to your vet about different treatment options.

Does Galliprant make dogs sleepy?

Galliprant can make dogs sleepy, as lethargy is a possible side effect of Galliprant. If you notice your dog has become drowsy, please ask your vet for advice.

Galliprant Datasheet

All drugs have a manufacturer’s datasheet, which gives information about the drug’s use and possible side effects. There is usually one in your Galliprant box, but if you have lost it you can click on the button below to be taken on an online version.

Courses related to Galliprant

Please note that the information contained herein is provided for informational purposes only. Although it has been written by a vet, we cannot consider the individual nature of your pet’s problems so it does not constitute veterinary advice. If you have questions about your pet’s medication or their health you should contact a vet, who will be able to help.

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